Mango Leaf Extract (Zynamite®)

Caffeine-Free Brain Energy and Mental Speed

In some cultures, mango leaf teas were consumed to support alertness and reduce tiredness, hinting at their early use for cognitive and mood benefits. Modern clinical research supports these traditional uses, showing that Zynamite® can enhance cognitive function, boost physical performance, and reduce fatigue, making it a unique dual-action nootropic and adaptogen.

Zynamite® improves cognitive performance by increasing neuronal activation and enhancing brain oxygenation. Studies show it can boost reaction time, accuracy, and mental fatigue resistance during tasks that demand focus.

Mechanisms include:

• Inhibition of monoamine oxidase (MAO): Supports neurotransmitter activity
• Antioxidant and anti-inflammatory action: Reduces brain fog caused by stress and fatigue
• Improved cerebral blood flow: Enhances mental alertness and working memory

Cognitive Benefits:

• Boosts reaction time, attention accuracy, and decision-making speed
• Enhances working memory and episodic recall
• Supports mental stamina and resilience under fatigue
• Works synergistically with ingredients like Lion’s Mane and Ginseng

Physical Performance Benefits

Zynamite® has also been clinically shown to support exercise performance, making it ideal for professionals who need both mental sharpness and physical stamina.

Key Benefits:

• Increases peak power output and muscle explosiveness
• Reduces exercise-induced oxidative stress and inflammation
• Delays the onset of fatigue during high-intensity activity
• Improves VO₂ kinetics (oxygen utilization) for endurance performance

Scientific References

1. Acute Cognitive Benefits in Healthy Adults

Study: Wightman et al. (2020) conducted a double-blind, placebo-controlled crossover study with 70 healthy adults aged 18–45. Participants received a single 300 mg dose of Zynamite® (≥60% mangiferin).

Findings:

• Significant improvements in overall cognitive accuracy across tasks.
• Enhanced performance in attention and episodic memory domains.
• Benefits observed at 30 minutes, 3 hours, and 5 hours post-dose.

Reference: Wightman et al., 2020

2. Enhanced Cognitive Performance with Soluble Zynamite® S

Study: A recent randomized, double-blind, placebo-controlled crossover study examined the effects of soluble Zynamite® S at doses of 100 mg and 150 mg on cognitive function and mood in young adults.

Findings:

• Improved processing speed, cognitive flexibility, and attention.
• Mood enhancement and reduced tension observed

Reference: Acute Supplementation of Soluble Mango Leaf Extract (Zynamite® S) Improves Mental Performance and Mood

3. Improved Sprint Performance and Muscle Oxygenation

Study: A study investigated the effects of a single dose of Zynamite® combined with quercetin on repeated-sprint performance and muscle oxygen extraction in men and women.

Findings:

• Enhanced peak power output during repeated sprints.
• Increased muscle oxygen extraction and mitochondrial oxygen consumption.

Reference: A Single Dose of The Mango Leaf Extract Zynamite® in Combination with Quercetin Enhances Peak Power Output During Repeated Sprint Exercise

4. Attenuation of Muscle Damage and Accelerated Recovery

Study: Martin-Rincon et al. (2020) examined the effects of Zynamite® combined with quercetin on muscle damage and recovery after strenuous exercise.

Findings:

• Reduced muscle damage and pain post-exercise.
• Accelerated recovery following intense physical activity.

Reference: Supplementation with a Mango Leaf Extract (Zynamite®) in Combination with Quercetin Attenuates Muscle Damage and Pain and Accelerates Recovery after Strenuous Damaging Exercise

5. Exercise-Mimetic Properties in Skeletal Muscle

Study: Martinez-Canton et al. (2023) explored the exercise-mimetic properties of Zynamite® combined with quercetin in human skeletal muscle.

Findings:

• Elicited muscle signaling changes resembling those induced by exercise training.
• Partially abrogated stress kinase responses to exercise.

Reference: A Mango Leaf Extract (Zynamite®) Combined with Quercetin Has Exercise-Mimetic Properties in Human Skeletal Muscle

Why We Chose It for Neurothena

Our audience demands clean, stimulant-free productivity. Zynamite delivers that edge, clean energy, fast focus, and resilience under pressure, without disrupting your sleep or spiking your stress hormones. It’s everything caffeine wishes it could be.

Fun Fact

Mangiferin, the key compound in Zynamite®, is found naturally in the leaves of wild mango trees and has been traditionally used in Ayurvedic medicine to relieve fatigue, increase energy and reduce inflammation.

Zynamite® is a trademark of Nektium.